Just a bit more on accommodating accessibility needs in your website. Here is an interesting article on creating an alternate stylesheet for low vision from Gez Lemon - Juicy Studio (Thanks to John Oxton for pointing it out.)
Looks like an intersting idea, we already create stylesheets for different media (screen/print), why not add another to accommodate for viewer with low vision that don't have access to or just don't use screen readers and instead can get by with zooming the text size?